Factors affecting decreased ovarian reserve among women of childbearing age / 预防医学

Objective@#To investigate the factors affecting decreased ovarian reserve (DOR) among women of childbearing age, so as to provide insights into prevention of DOR.@*Methods@#Women with DOR at ages of 18 to 40 years that were admitted to Department of Gynecology, Ningbo Women and Children's Hospital during the period from January 2021 to June 2022 were recruited (DOR group), while healthy women at ages of 18 to 40 years during the same period served as normal controls. Participants' demographics, exercise, diet, previous medical history, childbearing history and menstruation were collected using questionnaire surveys. The follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and estradiol (E2) levels were tested. Factors affecting DOR were identified among women of childbearing age using a multivariable logistic regression model.@*Results@#There were 200 participants in the DOR group, with a median (interquartile range) age of 32 (9) years, and 200 participants in the normal group, with a median (interquartile range) age of 29 (12) years. Multivariable logistic regression analysis showed that underweight (OR=2.935, 95%CI: 1.374-6.269), overweight/obesity (OR=2.612, 95%CI: 1.335-5.065), high-oil-high-glucose-high-salt diet (OR=2.653, 95%CI: 1.616-4.357), menstrual disorder (OR=1.977, 95%CI: 1.284-3.041) and lack of exercise (OR=3.392, 95%CI: 2.052-5.606) were statistically correlated with the development of DOR among women of childbearing age.@*Conclusions@#Underweight, overweight/obesity, high-oil-high-glucose-high-salt diet, menstrual disorder and lack of exercise are factors affecting the development of DOR among women of childbearing age.

La automedicación con anticonceptivos orales e inyectables en mujeres en edad fértil: resultados de un plan piloto / Self-medication with oral and injectable contraceptives in women of childbearing age: results of a pilot plan

La automedicación consiste en la selección y el uso de los medicamentos por parte de las personas, sin la participación del médico ni su prescripción, en este sentido es considerada como un fenómeno constante que se produce como consecuencia de necesidades y problemas de múltiples causas, sobre todo de índole económica. Materiales y métodos: Se realiza una investigación de campo, de corte transversal, tipo descriptiva. Se utilizó una prueba piloto para establecer la validez, pertinencia y coherencia para determinar el grado de confiabilidad del instrumento cuantitativo diseñado el cual fue validado por juicio de expertos. Se encuestó a 20 mujeres auto medicadas con anticonceptivo oral e inyectable, seleccionado de forma aleatoria. Resultados: en cuanto a la validación del instrumento se obtiene una puntuación de 99.4de validez, 99.2 de pertinencia y 99.4 de coherencia, en su totalidad de 298 dándonos como resultado final de 99.3 % de confiabilidad. Conclusión: el instrumento ha sido aprobado por su confiabilidad y validez, quedando apto para ser aplicados a la muestra que representa esta investigación(AU)

La automedicación consiste en la selección y el uso de los medicamentos por parte de las personas, sin la participación del médico ni su prescripción, en este sentido es considerado como un fenómeno constante que se produce como consecuencia de necesidades y problemas de múltiples causas, sobre todo de índole económica. Materiales y métodos: Se realiza una investigación de campo, de corte transversal, tipo descriptiva. Se obtuvo una prueba piloto para establecer la validez, pertinencia y coherencia para determinar el grado de confiabilidad del instrumento diseñado cuantitativamente el cual fue validado por juicio de expertos. Se encontró a 20 mujeres automedicadas con anticonceptivo oral e inyectable, seleccionadas de forma aleatoria. Resultados: en cuanto a la validación del instrumento se obtiene una puntuación de 99.4 de validez, 99.2 de pertinencia y 99.4 de coherencia, en su totalidad de 298 dándonos como resultado final de 99.3 % de confiabilidad. Conclusión: el instrumento ha sido aprobado por su confiabilidad y validez, quedando apto para ser aplicado a la muestra que representa esta investigación(AU)

Investigation and analysis of fertility intention and psychological pressure of women of childbearing age / 中国医师杂志

Objective:To investigate the fertility intention and psychological pressure of women of childbearing age in Yanshan County, Jiangxi Province, and to provide data support for the targeted promotion of fertility.Methods:Using the method of random sampling, women of childbearing age in 10 communities in Yanshan County, Jiangxi Province were given questionnaires and psychological stress rating tables to understand the basic information, the status of marriage and childbearing, childbearing intentions, and the Chinese version of the Perceived Stress Scale (CPSS) score, and explore the related factors that may affect childbearing intentions and psychological stress of women of childbearing age.Results:In this survey, 1 500 questionnaires were distributed to women of childbearing age, 913 of which were returned, and 65.0%(593/913) of them were willing to have children. The CPSS score of women of childbearing age was 8-28(16.84±2.75). The CPSS scores of women of childbearing age in different occupations were statistically significant ( P<0.05). Public officials (including civil servants and employees of public institutions) had the least psychological pressure, while self-employed and other (unemployed) had the most psychological pressure. There was no significant difference in CPSS scores among women of childbearing age with different education levels, annual income levels, marital status and willingness to have children (all P>0.05). The correlation analysis showed that there was a statistical significance between the psychological pressure of women of childbearing age and their occupation ( r=0.230, P<0.05), and there was no significant correlation between other factors such as education level, annual income, fertility desire, fertility status, etc. and psychological pressure (all P>0.05). Conclusions:The fertility intention desire of women of childbearing age in Yanshan County, Jiangxi Province is basically normal, and the desire to have more children is not strong. There is no significant correlation between fertility intention and psychological pressure. The psychological pressure of women of childbearing age is significantly related to their occupation.

Total mercury exposure risk and selenium content measuring on fishery products consumed by women of childbearing age from Bogota, Colombia / Riesgo de exposición a mercurio total y medición del contenido de selenio en productos de la pesca consumidos por mujeres en edad fértil de Bogotá, Colombia

Background: Dietary exposure to mercury in women of childbearing age could result in neurological effects on the fetus. A health risk assessment of total mercury by fishery products intake has not been conducted in this population group in Bogota, Colombia. On the other hand, it has been suggested that selenium content on fishery products may have a protective effect against mercury toxicity. Nevertheless, selenium content on fish species marketed in Bogota has not been determined. Objective: Exposure risk to total mercury and selenium content on fishery products consumed by women of childbearing age from Bogota, Colombia, were assessed. Methods: Total mercury and selenium concentrations for products available at fish stores and supermarkets were determined. The exposure risk to total mercury was estimated considering the intake of these products by women of childbearing age group. Results: Total mercury highest concentrations were 0.8166 mg/kg in mota (Calophysusmacropterus), and 0.6275 mg/kg in catfish (Pseudoplatystoma tigrinum). On the other hand, the highest selenium concentration was 0.6471 mg/kg in nicuro (Pimelodus blochii). Finally, it was established that for women of childbearing age group, health risk of exposure to total mercury due to mota intake exceeded by 8.56-fold the reference dose. Conclusions:Mota intake considerably increases exposure risk to total mercury on women of childbearing age from Bogota, Colombia. The selenium levels established in the fishery products assessed, except for catfish and mota, are theoretically suggestive of a protective effect of selenium against mercury toxicity. Consequently, continuous total mercury concentrations monitoring is required to protect health of women of childbearing age and the general population from Bogota, Colombia

Antecedentes: La exposición dietética al mercurio en mujeres en edad fértil podría provocar efectos neurológicos en el feto. En Bogotá, Colombia no se han realizado evaluaciones de riesgo por la exposición al mercurio total debido a la ingesta de productos de la pesca en este grupo de la población. Por otro lado, ha sido sugerido que el contenido de selenio en los productos de la pesca podría tener un efecto protector frente a la toxicidad por mercurio, sin embargo, el contenido de selenio en las especies de peces comercializadas en Bogotá, Colombia no ha sido determinado. Objetivo: Evaluar el riesgo de exposición al mercurio total y el contenido de selenio en los productos de la pesca consumidos por las mujeres en edad fértil de Bogotá, Colombia. Métodos: Se determinaron las concentraciones de mercurio total y selenio en distintos productos de la pesca disponibles en pescaderías y supermercados. El riesgo de exposición a mercurio total se estimó considerando la ingesta de estos productos por parte de un grupo de mujeres en edad fértil. Resultados: Las concentraciones más altas de mercurio total fueron de 0.8166 mg/kg en mota (Calophysus macropterus) y 0.6275 mg/kg en bagre (Pseudoplatystoma tigrinum). Por otro lado, la concentración más alta de selenio fue de 0.6471 mg/kg en nicuro (Pimelodus blochii). Finalmente, se estableció que el riesgo de exposición a mercurio total, debido a la ingesta de mota, excedió en 8.56 veces la dosis de referencia en el grupo de mujeres en edad fértil. Conclusiones: La ingesta de mota aumenta el riesgo de exposición al mercurio total en las mujeres en edad fértil de Bogotá, Colombia. Por otro lado, los niveles de selenio identificados en los productos evaluados, excepto en bagre y mota, teóricamente sugieren un posible efecto protector del selenio contra la toxicidad por mercurio. Considerando lo indicado, es necesario realizar un monitoreo continuo de las concentraciones de mercurio total en los productos de la pesca, con el fin de proteger la salud de las mujeres en edad fértil y de la población general de Bogotá, Colombia

Relación entre ingesta dietética y estado nutricional del hierro en mujeres chilenas en edad fértil de una comunidad universitaria

RESUMEN Propósito: Relacionar la ingesta dietaria de hierro con el estado nutricional de éste en una muestra de mujeres en edad fértil de Santiago de Chile. Método: A 51 mujeres entre 18 - 35 años se aplicó una Encuesta de Tendencia de Consumo para estimar el aporte de hierro dietario, junto con la medición de los biomarcadores bioquímicos a modo de determinar el estado de los depósitos de hierro. Mediante prueba estadística de Mann-Whitney se analizaron diferencias significativas entre los grupos según estado nutricional del hierro y sus parámetros sanguíneos. Resultados: Treinta y siete de las participantes (72,5%) no cumple con la ingesta recomendada de hierro diario. Dos de las mujeres presentaron anemia, 2 deficiencia de hierro sin anemia y 12 tenía los depósitos de hierro depletados. Tres de las mujeres que presentaron depósitos deficientes tuvieron una ingesta de hierro adecuada, mientras que el 71% de las mujeres con depósitos normales presentaron una ingesta de hierro insuficiente. Conclusiones: Hay un bajo cumplimiento de los requerimientos diarios de hierro y no se observan mejores valores hematológicos a mayor ingesta de hierro, a pesar de presentar un alto porcentaje con depósitos normales de hierro. Se requiere mayor análisis de la alimentación de este grupo de la población para identificar el tipo de hierro que se está aportando principalmente y si hay otros factores dietarios y no dietarios afectando los depósitos de hierro.

ABSTRACT Objectives: To relate dietary intake of iron with iron status in a sample of women of childbearing age from Santiago de Chile. Methods: A Food Frequency Survey was applied to 51 women between 18 - 35 years of age to estimate intake of dietary iron, together with the measurement of biochemical biomarkers to determine iron stores. Using the Mann-Whitney statistical test, significant differences were analyzed between the groups according to nutritional status of iron and its blood parameters. Results: Thirty seven of the participants (72.5%) do not meet the recommended daily iron intake. Two had anemia, 2 had iron deficiency without anemia, and twelve had depleted iron stores. Three women with deficient iron stores had an adequate iron intake, while 71% of women with normal iron stores showed an insufficient iron intake. Conclusions: We observed a low compliance with the daily iron requirements and no better hematological values were associated with higher iron intake, despite a high percentage of women with normal iron stores. To identify the type of iron mainly contributed by the diet and if there are other dietary and non-dietary factors affecting iron stores, further analysis of this population group is required.

Epidemiological analysis of human papillomavirus infection in women of childbearing age in Shaanxi / 公共卫生与预防医学

Objective To explore the epidemiology of human papillomavirus infection in women of childbearing age in Shaanxi Province. Methods A stratified random sampling method was used to select 16705 patients under childbearing age in Shaanxi from January 2015 to January 2020, and 857 healthy patients who had physical examination during the same period were selected as the control group. The general information of patients was obtained through questionnaire survey, and the risk factors were analyzed by single factor and multivariate logistic analysis. Results The detection rate of human papillomavirus infection in 16705 cases was 2570 (15.38%), of which 1972 cases of high-risk type (11.80%) were higher than 598 cases (3.58%) of low-risk type (χ2: 795.77, P 2: 259.08, P <0.001).The proportions of younger than 30 years old, sexual life ≥3 times/week, no condoms, cervical erosion, and smoking were higher in high-risk human papillomavirus infection group than the control group (P<0.05). After multivariate logistic regression analysis, the results showed that the frequency of sexual life and the greater degree of cervical erosion were independent risk factors for high-risk human papillomavirus infection [OR (95% CI): 3.112 (1.607~7.702), 4.209 (2.338~ 12.526, P<0.05], the use of condoms is a high-risk protective factor for human papillomavirus infection [OR(95%CI): 0.674 (0.578~0.699, P<0.05]) Conclusion The frequency of sexual life and the degree of cervical erosion are high in women of childbearing age in Shaanxi. The use of condoms can effectively prevent human papillomavirus infection. Reasonably formulating effective intervention measures and vigorously publicizing the knowledge of human papillomavirus prevention and treatment is the key to reducing human papillomavirus infection in women of childbearing age in Shaanxi.

Knowledge about clinical presentation, prevention strategies and sexual transmission of Zika virus infection among women of reproductive age in an endemic area

ABSTRACT Background The recognition of the causal association between Zika virus (ZIKV) infection during pregnancy and congenital abnormalities including microcephaly underlines the importance of preventing this disease in pregnant women (PW) and women of childbearing age (WCA). Although Brazil and other Latin American countries reported a significant reduction in the number of ZIKV infections in recent years, epidemic waves can recur in settings with previous outbreaks as conditions for transmission remain optimal and susceptible populations are continuously replenished. Methods: In this cross-sectional study, we enrolled 64 PW and 260 non-pregnant WCA attending routine medical appointments in two primary care units in São Paulo, Brazil, and assessed knowledge and attitudes about ZIKV infection and prevention. Results: Most women reported knowing that ZIKV is transmitted through the bite of Aedes mosquitos, and most knew that acute symptoms are similar to those seen in Dengue infection. Furthermore, most participants correctly described that ZIKV infection during pregnancy may cause detrimental outcomes for the newborn. However, most ignored that ZIKV infection can be asymptomatic, and only 15% knew about the risk of ZIKV sexual transmission. We found no statistically significant differences between PW and WCA regarding knowledge about ZIKV sexual transmission. Knowledge about ZIKV sexual transmission was significantly associated with education; among participants with ≤12 schooling years, only 9.0% (95%CI 3.4-18.5%) correctly answered that ZIKV can be sexually transmitted, compared to 12.9% (95%CI 8.2-18.8%) among participants with 12-14 schooling years, and to 24.4% (95%CI 15.9-34.9%) of participants with ≥15 schooling years (p = 0.015). Education remained independently associated with knowledge about sexual transmission of ZIKV in a multivariate logistic regression model adjusted for age, race and pregnancy status (p = 0.022). Conclusion: Our findings underscore the urgent need of educational and family planning programs that may help prevent detrimental outcomes of ZIKV infection in an endemic area of Brazil.

Factors Influencing HIV Knowledge Among Women Of Childbearing Age In South Sumatra, Indonesia

@#This study aims to provide detailed information on the role of the following social determinants (i.e. education, occupation, place of residence, marital and economic status) in the acquisition of HIV knowledge among women of childbearing age (15-49 years old). The study uses secondary data from the 2012 Indonesian Demographic and Health Survey (IDHS). The IDHS used a quantitative analytical approach with a cross-sectional study design and multi-stage stratified sampling. The sample included 1,335 women aged 15 to 49 years old living in South Sumatra Province, Indonesia. Descriptive analysis, ANOVA, and t-test and multiple logistic regressions were performed in this study. The results show one out of two women have little HIV knowledge. The more highly educated women were positively associated with a greater degree of knowledge related to comprehensive knowledge related to HIV (AOR: 3.7, 2.2-6.2, p.<0.05), HIV prevention (AOR:16.6, 1.8-153.9, p <0.05), transmission from mother to child (AOR:11.1, 3.3-36.9, p <0.05), HIV misconceptions (AOR:5.1, 1.1-23.1, p <0.05) and HIV services (AOR:5.7, 2.8-11.4, p < 0.05). In addition, the women lived in urban areas had more knowledge related to HIV prevention and transmission (AOR: 3.36, 1.8-6.2, p <0.05), and knowledge about mother-to-child of HIV transmission (AOR: 3.2, 1.8-5.5, p <0.05) compared to those who lived in rural areas. To conclude, education level was found to be the dominant factor associated with knowledge of HIV across all categories of knowledge after controlling by other determinants, age, marital status, working status and residence. HIV awareness and comprehensive HIV information among women who are considered to be in a low-risk group for HIV infection should be integrated with formal education as well as in maternal health services, particularly in rural areas.

Detection of parvovirus B19 viral DNA in serum of women of childbearing age in Xiangyang City / 公共卫生与预防医学

Objective To analyze the infection of human parvovirus B19 among women of childbearing age in Xiangyang City, and to provide a reference for pregnant women's health care. Methods A total of 303 women of childbearing age in Xiangyang City from 2018 to 2019 were selected as the research subjects. B19 virus DNA in serum of the subjects was detected by nested PCR technology. The differences in the detection rate of B19 viral DNA among normal pregnancy, abnormal pregnancy, and infertility serum were statistically analyzed. The differences in the detection rate of B19 virus DNA among women of childbearing age at different ages were compared. Results The detection rate of B19 viral DNA in all 303 women of child-bearing age was 27.72%. The detection rate of B19 virus DNA in 26-35 year old women was higher than that in other age groups. The detection rate of B19 virus DNA in abnormal pregnancy group was significantly higher than that in normal pregnancy group (P <0.05). Conclusion The detection rate of B19 virus DNA in abnormal pregnancy and infertility group was significantly higher than that in normal pregnancy group, with the detection rate of B19 virus in 26-35 year old women of childbearing age being the highest among all age groups. It is necessary to strengthen the screening of B19 virus in pregnant women of childbearing age in this region to reduce its impact on fetal abortion.

Status quo investigation on induced abortion in 1 065 women of childbearing age in Wenzhou / 上海预防医学

Objective To investigate the service needs in relation to the related behavioral characteristics and reproductive health service for women receiving induced abortion in childbearing age in Wenzhou, providing reference for the protection of reproductive health in women of childbearing age. Methods A questionnaire survey was conducted among a total of 1 065 women of childbearing age who received artificial abortion in 12 medical institutions and maternal and child health care institutions in Wenzhou. Results Of the 1 065 women, 456 (42.82%) were under 24 years old, 609 (57.18%) were over 25 years old.815 (76.53%) with high school / technical secondary school degree or below, 250 (23.47%) with college degree or above.448 unmarried (42.07%), 617 married (57.93%).484 (45.45%) of first abortion and 581 (54.55%) of repeated abortion.Among the direct causes of abortion, 244 (54.46%) were not contraception, 382 (61.91%) were contraception failure.There was a significant difference in the direct causes of induced abortion among women with different marital status(χ2＝28.128, P < 0.05).67.51% of the surveyed women hoped that the family planning clinic would provide contraceptive and reproductive health consulting services after abortion. Conclusion Women of childbearing age with induced abortion in Wenzhou have low education level, high rate of repeated abortion, lack of contraceptive knowledge and high demand for contraceptive and reproductive health consulting services.Therefore, it is necessary to improve reproductive health education, popularize contraceptive knowledge, reduce abortion rate and promote reproductive health.

Incidence trend of gestational diabetes mellitus in Hangzhou from 2009 to 2018 / 预防医学

Objective @#To learn the incidence trend of gestational diabetes mellitus (GDM) among women of childbearing age in Hangzhou from 2009 to 2018, providing evidence for GDM prevention and control.@*Methods@#The information of GDM cases aged 15 to 49 years in Hangzhou from 2009 to 2018 was extracted from Zhejiang non-communicable diseases surveillance system. The crude and age-standardized (by national standard population in 2000) incidence rate of GDM were calculated, the annual change percentage (APC) and the average APC (AAPC) of GDM incidence rate were calculated to understand the trend of incidence in different age groups and areas. @*Results@#A total of 45 519 cases of GDM were reported in Hangzhou from 2009 to 2018. The crude and age-standardized incidence rates were 248.04/100 000 and 158.52/100 000, respectively, both showed upward trends with 59.7% and 56.4% in AAPC (both P<0.05). The APCs of crude and age-standardized incidence rates of GDM were 139.76% and 134.60% from 2009 to 2012, 30.35% and 27.65% from 2012 to 2018, which all had increasing trends (all P<0.05). There were upward trends in GDM incidence in each age groups of 15-24, 25-29, 30-34, 35-39 and 40-49 years old (all P<0.05). The AAPC of GDM incidence in 40-49 year-old women was 65.3% and ranked the first among all the age groups. The age-standardized incidence rate of GDM increased more in rural areas (AAPC=66.0%) than in urban areas (AAPC=53.4%). @*Conclusion@# A rising trend in GDM incidence among women aged 15-49 years in Hangzhou has been found in recent ten years, especially in women aged 40-49 years and lived in rural areas.

Reproductive safety of bisphosphonates in women of childbearing age / 中华内分泌代谢杂志

Bisphosphonates ( BPs) are bone resorption inhibitors, which are increasingly used in the treatment of bone metabolic diseases in women of childbearing age. It is unclear whether the use of BPs in women of childbearing age will affect the health of their offspring. This article retrieved 66 reports in the past 40 years by searching on the databases of Pubmed, Embase, Ovid, Medline and so on. A number of reports found that BPs may be responsible for shortening gestational age, increasing spontaneous abortion, and decreasing neonatal birth weight. Three women's offsprings were found to have abnormal blood calcium after birth. Cases of skeletal malformations include two bilateral talipes equinus, one Apert's syndrome and one rickets. However, there have been many reports of no reproductive abnormalities or abnormal blood calcium level. Occasionally, children breast-fed by women who had received BPs have had a transient hypocalcemia. There is currently insufficient evidence to confirm that BPs can cause significant reproductive malformations during pregnancy or pre-pregnancy. However, due to the long-term presence of BPs in the bones, women of childbearing age who have a need for pregnancy should choose to use these drugs with caution.

Consensus on clinical management of hepatitis B virus- infected women of childbearing age / 中华肝脏病杂志

The mother-to-child transmission(MTCT) of hepatitis B virus (HBV) is the dominant cause of chronic HBV infection. In order to achieve the goal of "zero" MTCT before pregnancy, during pregnancy, and after pregnancy; standardized management for hepatitis HBV infection in women of childbearing age should be regulated. The content of this consensus includes: screening and treatment of HBV in pregnant women and women of childbearing age, treatment of hepatitis B during pregnancy, preventive measures and evaluation of combined immunization of hepatitis B immunoglobulin and hepatitis B vaccine in newborns, anti-viral therapy for all pregnant women with a high HBV DNA level and post-partum period related management. In addition, 16 recommendations were formed for clinicians to standardize the clinical management of HBV infection in women of child-bearing age.

Status of AMH in Serum of Healthy Women in Shenzhen Area and Its Value in PCOS and POF Treatment / 现代检验医学杂志

Objective To investigate the current status of anti-mullerian hormone (AMH) in healthy women in the healthy childbearing age in Shenzhen area,and to explore its application value in polycystic ovary syndrome (PCOS) and prature ovarian syndrome (POF) treatment.Methods Collected 860 cases of medical health women of childbearing age in Shenzhen BaoanDistrict People's Hospital from January 2016 to March 2017 as control group,and at the same time selected 59 cases of patients with PCOS and 61 cases of patients with POF as observation group.Adopted DXI800 chemiluminescence analyzer to test serum AMH level of control group,patients with PCOS and POF group respectively before and 3 months after treatment,and the testing results were analyzed.Results The serum AMH level of Healthy women of childbearing age was 4.91 ±1.56 ng/ml,18～25 years old group was 5.38±1.27 ng/ml,31～35 and 36～42 years old group were 4.53±1.40 ng/ml and 3.95±1.16 ng/ml,being all lower than that in group 18～25 years old (t=3.082,5.066,all P＜0.05).While 26～30 years old group was 5.09± 1.45 ng/ml,and compared with 18～ 25,there was no statistically significant difference (t=0.892,P＞0.05).Before the treatment,the serum AMH level of PCOS was 10.13± 3.85 ng/ml,significantly higher than the control group,the difference was statistically significant (t=13.924,P＜0.01),while the serum AMH level of POF group and wait POF patients were 1.04±0.37 ng/ml and 2.39±0.87 ng/ml,significantly lower than the control group (t=10.913,8.042,all P＜0.05),and POF lower than wait POF group (t=2.875,P＜0.05).After treatment,the serum AMH level of PCOS was 5.22± 1.58 ng/ml,significantly lower than before treatment (t =11.106,P＜0.05),and there was no statistically significant difference between control group (t=1.036,P＞0.05),the serum AMH level of POF and wait POF were 4.49±1.32 ng/ml and 4.54± 1.47 ng/ml,significantly higher than the before treatment (t=9.608,7.253,all P＜0.05),and compared with the control group there were no statistically significant differences (t =1.209,0.918,all P＞0.05).Conclusion Before the treatment,the serum AMH levels of PCOS were increased significantly,and the serum AMH levels of POF and wait POF patients were significantly reduced,while the serum AMH levels of PCOS,POF and wait POF patients were all restored to normal levels after treatment.Therefore,AMH has certain application value in the diagnosis and treatment evaluation of women PCOS and POF disease.

Análisis epidemiológico de las patologías en mujeres de edad reproductiva que acudieron a un hospital general tipo IV / Epidemiological analysis of medical conditions in women of childbearing age who attended a teaching general hospital in Caracas, Venezuela

Analizar la patología médica de las mujeres en edad fértil que fueron atendidas en el Hospital General del Oeste de Caracas, Venezuela. Métodos: se realizó un estudio descriptivo, transversal, de pacientes con edades entre 14 y 44 años evaluadas desde 1º Octubre 2015 al 1º Mayo 2016. Tratamiento estadístico: Se realizó estadística descriptiva con medidas de tendencia central en las variables continuas y de proporción en las cualitativas. Resultados: Se evaluaron 910 pacientes con edad promedio de 25,63 ± 6,69 DS. El grupo entre 14 y 19 años fue el 33,40% y el 17,5% eran adolescentes. El promedio de edad de las embarazadas fue de 23,31 ± 6,08 DS, mientras que en las no gestantes 30,57 ± 7,97 DS. Según el Graffar modificado por Méndez Castellanos predominó la clasificación III en 57,06%. El promedio de la menarquia fue 12,7 ± 1,75 DS y de la sexarquia 16,54 ± 4,04 DS. La edad promedio del primer parto fue 18 ± 1,33 DS. El 73,62% no cumplía control ginecológico anual. Eran gestantes 78% y de ellas, el 80% eran sanas. Las patologías médicas del embarazo fueron preeclampsia 39%, anemia 35,93%, diabetes gestacional 12%, síndrome de HELLP 11%, hiperemesis gravídica 1,56%. Los diagnósticos médicos no relacionados con el embarazo fueron: asma 41,77%, HTA crónica 16,45%, ITU 12,65%, obesidad 7,59%, anemia 5,09%. La violencia doméstica se documentó en 3,4% y 20% ocurrió durante la gestación. En las no gestantes el diagnóstico médico predominó en 48% y los mas frecuentes fueron: anemia 34,84%, ITU 27,77%, HTA crónica 7,57%. Conclusión: La atención médica de la mujer en edad reproductiva debe ser adecuadamente abordada(AU)

To analyze the medical conditions in women of childbearing age who consulted at the Hospital General del Oeste, Caracas, Venezuela. Methods: This is an analitycal, transverse case design, of female patients in a non probabilistic sample, of intentional selection, that included 100% of patients aged 14 - 44 years, who consulted between October 1st 2015 and May 1st 2016- We included hospitalized and outpatients of internal medicine, as well as obstetrics and gynecology. A previous informed consent was obtained. The sample was divided in two groups, pregnant and not pregnant, classified as healthy and with any medical or gynecological pathology. The variables studied were: age, menarche, sexarche, parity, demographics, and final diagnoses, as well as associated complications. Results: We studied 910 patients, with an average age of 25,63 ± 6,69 DS. The group of 14 to 19 years was 3,40% and 17,5% of them were adolescents. The average age of the pregnant women was 23,31 ± 6,08 DS, and in the non-pregnant 30,57 ± 7,97 DS The Graffar score modified by Méndez Castellanos showed a class III in 57,06%. The average age of menarche was 12,7 ± 1,75 DS and of the first sexual intercourse 16,54 ± 4,04 DS. The average age of the first delivery 18 ± 1,33 DS. An important 73,62% did not have an annual gynecological consultation. The pregnant women were 78%. Among them, 80% were healthy. Their pathological conditions of pregnancy were: preeclampsia 39%, anemia 35,93%, gestational diabetes 12%, HELLP syndrome 11%, hyperemesis gravídarum 1,56%. The medical conditions not related to pregnancy were: asthma 41,77%, chronic hypertension 16,45%, UTI 12,65%, obesity 7,59%, anemia 5,09%. Doméstic violence was documented in 3,4%, and 20% ocurred during pregnancy. In non pregnant women there was 48% of medical conditions, being the most frequent anemia 34,84%, UTI 27,77%, chronic hypertension 7,57%, Conclusion: Women in childbearing age must be adequately approached and treated(AU)

Study on the feasibility and safety of measles vaccination in women of childbearing age / 中华传染病杂志

Objective To study the feasibility and safety of measles vaccination in women of childbearing age and to understand the influence of measles vaccination on the fetal transmission measles antibody level of the infants.Methods From January 1,2012 to December 31,2012,600 women of childbearing age were included in this study.The measles IgG antibody was detected,then all participants were randomized according to the IgG level.The measles IgG antibody of participants in non-vaccinated group was detected predelivery in hospital by enzyme linked-immunosorbent assay (ELISA).That of participants in vaccinated group was detected 3 months after vaccination with measles mumps rubella combined vaccine and predelivery by ELISA.And measles nuclear protein fragment gene (measles virus nucleoprotein,MVN) in the blood was detected by reverse transcription polymerase chain reaction (RT PCR).A total of 368 participants gave birth within 2 years after vaccination,and 357 infants 8 months after birth were healthy.In non-vaccinated group,8 infants were diagnosed with measles within 8 months after birth.Finally,349 8-month infants were enrolled in the study,including 52 whose mothers in high antibody without vaccination group,65 whose mothers in high antibody with vaccination group,110 whose mothers in low antibody without vaccination group and 122 whose mothers in low antibody with vaccination group.The measles IgG antibody levels in the blood of all the 8-month infants were detected.Data were analyzed using t test,one-way ANOVA (Newman-Keuls was used for comparison between groups) and Pearson analysis.Results The measles IgG antibody level of expectant women in high antibody without vaccination group was significantly lower compared to that in high antibody with vaccination group ([268.5±74.9] IU/mL vs [578.3t208.1] IU/mL,Q=15.57,P＜0.01).That in low antibody without vaccination group was also significantly lower than low antibody with vaccination group ([169.4+42.3] IU/mL vs [584.7+195.8] IU/mL,Q=29.54,P＜0.01).The results of MVN RT-PCR after 3 months of vaccination showed no positive bands in all blood samples.Two of the expectant women in high antibody without vaccination group and one in low antibody without vaccination group were positive for MVN bands.Among 8-month infants,the levels of antibody in high antibody without vaccination group and high antibody with vaccination group were (106.3 ± 36.8) IU/mL and (291.8±86.5) IU/mL,respectively,which was statistically different (t=23.33,P＜0.01).Those in low antibody without vaccination group and low antibody with vaccination group were (87.1 ± 26.4) IU/mL and (274.0±72.5) IU/mL,respectively,which was statistically different (t =33.27,P＜0.01).The measles antibody level of expectant women was positively correlated with their 8-month infants (r=0.652,P＜0.01).All 8 infants who were diagnosed with measles were delivered by women without vaccination,and the measles infection rate of infants was significantly different between women with and without vaccination (P=0.002).Condusion It is feasible for women of childbearing age to receive measles vaccination,which can increase the measles IgG antibody level of both expectant women and their infants.

Infecciones de transmisión sexual en mujeres de edad fértil usuarias del Hospital Regional de Villa Hayes, Paraguay / Sexually transmitted infections in childbearing agewomen attending at the Regional Hospital of VillaHayes, Paraguay

Las Infecciones de Transmisión Sexual (ITS) se encuentran entre las cinco razones de consulta más frecuente en adultos. En Paraguay existe un conocimiento limitado sobre frecuencia de ITS especialmente en mujeres no gestantes en edad fértil. Por ello, este estudio piloto descriptivo de corte transverso analizó la frecuencia de sífilis, de infección por el Virus de la Inmunodeficiencia Humana (VIH) de factores de riesgo asociados en 100 mujeres en edad fértil (18-48 años) no gestantes que acudieron al Hospital Regional de Villa Hayes. La detección de sífilis se realizó mediante el método inmunocromato-gráfico y la confirmación por la Prueba de Absorción de Anticuerpos Treponémicos Fluorescentes. La infección por VIH fue detectada mediante el método inmunocromatográfico y el Ensayo por Inmunoabsorción Ligado a Enzimas. Se consideró un conocimiento aceptable sobre prevención y transmisión de estas ITS si el 60% de las preguntas se contestaban correctamente. Se observó una alta frecuencia de sífilis, de 13% (IC95%7,1-21,2%) y una asociación entre el bajo nivel educativo y la presencia de sífilis (p=0,002). No se encontró ningún resultado positivo para VIH. El 11% de las mujeres presentó un nivel inaceptable de conocimiento, sin embargo se evidenció una alta frecuencia de mujeres (58%) que no utilizaba preservativo, lo cual indica falta de buenas prácticas. Es preciso fortalecer las medidas de control y manejo de ITS ya existentes en esta región especialmente en las mujeres no gestantes en edad fértil.

Sexually Transmitted Infections (STIs) are among the five most frequent reasons forconsultation in adults. In Paraguay there is a limited knowledge about STIs frequencyespecially in non pregnant women of childbearing age. Therefore, this pilot descriptivecross-sectional study analyzed the frequency of syphilis, HIV infection and associatedrisk factors in 100 women of childbearing age (18-48 years) non pregnant who went tothe Regional Hospital of Villa Hayes. Syphilis screening was performed using the immu nochromatography method and confirmation by the Test Fluorescent Treponemal AntibodyAbsorption. HIV infection was detected by the immunochromatographic methodand the test for enzyme-linked immunosorbent. An acceptable knowledge about preventionand transmission of these STIs were considered if 60% of the questions wereanswered correctly. A high frequency of syphilis, about 13% (CI95%7.1-21.2%) and anassociation between low educational level and the presence of syphilis (p = 0.002) wasobserved. No positive result for HIV was found. 11% of women presented an unacceptablelevel of knowledge, however a high frequency of women (58%) who did not usecondoms was evident, indicating lack of good practices. It is necessary to strengthencontrol measures and management of STIs existing in this region especially in nonpregnantwomen of childbearing age.

The evaluation of taking the opportunity of family planning B ultrasound check of married women in childbearing age to carry out anti AIDS education / 中国医师杂志

Objective To explore the married women of childbearing age education on HIV/AIDS intervention method, curb the spread of HIV.Methods Use family planning check B to exceed three op-portunity, for married women of childbearing age to carry out the publicity and consultation, and design a u-nified questionnaire, respectively in the survey of 500 were statistically analyzed before and after the inter-vention, effect evaluation in description epidemiological methods.Results Before and after the interven-tion, the AIDS knowledge awareness rate of married women of childbearing age was 62.75%(2183/3479) , 97.36%(3360/3451),attitudes to AIDS positive response rate was 65.19%(324/497), 95.94%(473/493), middle school students knowledge of AIDS awareness rate was 90.48% (5130/5670), 96.99%(5110/4956 ) , the villagers'awareness rate of AIDS related knowledge was 69.61% ( 2183/3136 ) , 97.36% (3360/3451) .After the intervention, the AIDS knowledge awareness and attitude to HIV positive answer rate of married women of childbearing age were significantly improved,middle school students, vil-lagers AIDS awareness rate were significantly higher than those before intervention.Conclusions The use of B-three examinations opportunities for married women in AIDS prevention knowledge of educational inter-vention improves the life skills of women of childbearing age to prevent AIDS, and to take advantage of the core and the influence of women of childbearing age in the family will spread AIDS prevention knowledge, radiation to family members and the community to improve AIDS prevention capacity of the whole society, to curb the AIDS epidemic.

Study on the related factors of prenatal health care among floating women in five cities of China / 中华流行病学杂志

Objective To understand the current status of prenatal health care(PHC) and its related factors for floating women of childbearing age,and to provide evidence for improving the quality of PHC at childbearing age.Methods With data from the reproductive health survey on floating population in five cities,Beijing,Nanjing,Xiamen,Shenzhen and Chongqing,in 2005,the distributions of PHC among floating women were described.Multivariate logistic regression was performed to investigate the factors related to the utilization of PHC.Results In 5 399 cases of valid questionnaires,4 037 floating women who had the history of pregnant,cases who had or did not have PHC services would account for 75.3％ (3 041/4 037) and 24.7％ (996/4 037),respectively.The initial time of using the PHC service was significantly associated with the level of their education (P＜ 0.05) received.Data from the multivariate logistic regression analysis in PHC showed that there were differences between regions (P＜0.05).Proportions of women receiving PHC among those under 30 years and 30-39 were 4.09-folds (95％ CI:3.11-5.39) and 1.98-folds (95％ CI:1.61-2.43),respectively,when compared with that of women over 40-year-old.The proportion of women having received PHC with education levels of senior high school and above or junior high school,were 5.47-folds (95％CI:3.85-7.77) and 2.86-folds (95％CI:2.42-3.39) respectively,compared to that of women with education level of primary school or below.The proportion of married women having PHC was 2.36-folds (95％CI:1.07-5.22) of those unmarried women.The proportions of having PHC of women with one parity and two parities or with family planning certificate were 3.36-fold (95％CI:2.33-4.84) and 1.61-fold (95％CI:1.12-2.30),1.44-folds (95％CI:1.21-1.71) respectively,when compared with those women with three parities or without the certificate.Conclusion Factors as having received higher education,being married,with less parities or having family planning certificate etc.showed protective effects on PHC for floating women of childbearing age.Based on PHC,education should be promoted among the floating women of childbearing age,which would contribute to the prevention and reduction of adverse outcomes related to reproductive health.

Impact of intrauterine device insertion surgery on women's mental state / 中华妇产科杂志

Objective To evaluate the impact of the intrauterine device (IUD) insertion on the mental state of women.Methods From Jan.2009 to Jun.2010,a multi-center clinical observational study was performed.Totally 641 women were selected in the six provinces' 18 family planning service stations and hospitals for IUD insertion surgery study.Analysis of the change of women's mental state which was evaluated by symptom checklist-90 (SCL-90) scale before and after IUD insertion surgery.Results Before and after IUD insertion surgery,10 factors' scores in SCL-90 of the observed objects were between 1.1 to 1.2,total scores were 107 ± 27 and 105 ± 25,respectively.Before and after surgery,total average score both were 1.2,the average score of positive items both were 2.1.The difference of the above results were not statistically significance (all P ＞0.05).Preoperative and postoperative,the rate of positive items was 9.2％-19.6％ and 7.7％-17.6％,respectively.In addition to anxiety and fear,the rate of other factors' positive items postoperative was significantly lower than those in the preoperative (all P ＜ 0.05).The incidence of the observed objects postoperative of each factor score,deteriorated was in the range of 4.9％ to 23.0％,improved was in the range of 26.3％-50.1％.The incidence of total scores,deterioration was 28.8％ (166/575),improved was 45.6％ (262/575).The incidence of the average score of positive items,deterioration was 3.7％ (21/575),improved was 52.3％ (301/575).Logistic analysis showed that,in addition to unit level,there were no other significant influencing factors for women' mental state of postoperative (all P ＞ 0.05).Conclusion IUD insertion surgery has no adverse effect on women's mental state.